Tuesday 2 August 2016

The RNA

RNA is a long polymer of ribonucliecotides. And a ribonucliecotide is made up of a Ribose sugar, phosphate and bases such as Adenine, Guanine, Cytosine and Uracil. Well, RNA was discovered with DNA by Friedrich Meischer and termed them as 'nuclein'. Ribonucleic acid (RNA) is a polymeric molecule implicated in various biological roles in coding, decoding, regulation, and expression of genes.




RNA was the first genetic material. There are evidences to suggest that essential life processes, such as metabolism, translation, splicing etc. evolved around RNA. RNA used to act as a genetic material as well as a catalyst. There are some important biochemical reactions in living systems that are catalysed by RNA catalyst (ribozyme) and not by protien enzyme e.g., Ribonucleases R (Cleavage), Snurps (splicing), Peptidyl transferase (peptide bond formation).
But RNA being a a catalyst was reactive and hence unstable. Therefore, DNA has evolved from RNA with chemical modifications that makes it more stable. DNA being double stranded and having complementary strand further resists changes by evolving a process of repair.
RNA is adapter, structural molecule and in some cases catalytic. So from the above discussion it is very much clear both RNA and DNA can function as genetic material, but DNA being stable is preferred for storage of genetic material. For the transmission of genetic information RNA is better material.

Types of RNA
Name of the RNA Location inside the cells Features Amount from total RNA Functions
mRNA (m-messenger) In the cytoplasm. mRNA is the most heterogeneous of the 3 types of RNA in terms of both base sequence and size. 5% It carries the genetic code copied from the DNA during transcription in the form of triplets of nucleotides called codons.
rRNA (r-ribosomal) In ribosomes. Ribosomes are composed of a large subunit called the 50S and a small subunit called the 30S, each of which has its own rRNA molecules. 80% rRNAs combine with proteins in the cytoplasm to form ribosomes, which act as the site of protein synthesis and has the enzymes needed for the process. These complex structures travel along the mRNA molecule during translation and facilitate the assembly of amino acids to form a polypeptide chain. They bind to tRNAs and other molecules that are crucial for protein synthesis.
tRNA (t-transfer) Mainly cytoplasm. tRNA is the smallest of the 3 types of RNA having about 75-95 nucleotides. 15% (well 100-80+5 =15) tRNAs are an essential component of translation, where their main function is the transfer of amino acids during protein synthesis.
For more details on specific RNA check the next post.
Well How do the life originated, give your own opinions after watching the video below in the comments.

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